These US AI Startups Raised $100M+ in 2025 – Here’s Why Investors Are Betting Big

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6 months ago

Meet these US based AI Startups Dominating 2025 With $100M+ in Funding. The artificial intelligence (AI) industry is witnessing an unprecedented boom in 2025, with multiple startups securing massive funding rounds. Investors are pouring billions into AI-driven innovations, signaling the sector’s rapid expansion and its potential to redefine industries such as healthcare, legal tech, infrastructure, and automation.

In this article, we explore US-based AI startups that have raised $100 million or more this year, highlighting their groundbreaking contributions to AI technology and what the future holds for them.

The Rise of AI Startups in 2025

The AI landscape has been evolving at a breakneck pace, with startups pioneering advancements in generative AI, AI hardware, and AI-driven enterprise solutions. Large venture capital firms, as well as tech giants, are increasingly investing in AI startups, believing in their potential to revolutionize industries across the board.

Here are the nine US-based AI startups that have secured funding rounds of $100 million or more in 2025:

1. Anthropic ($3.5 Billion Series E)

Valuation: $61.5 billion
Specialization: AI research, large language models
Key Investors: Lightspeed, Salesforce Ventures, Menlo Ventures, General Catalyst
Why It Matters: Anthropic is at the forefront of AI research, developing Claude AI, an advanced chatbot rivaling OpenAI’s ChatGPT. Its massive funding boost is expected to fuel further research and commercial applications of generative AI.

Meet the US Based AI Startups Dominating 2025 With $100M+ in Funding

2. Together AI ($305 Million Series B)

Valuation: $3.3 billion
Specialization: Open-source generative AI, AI infrastructure
Key Investors: Prosperity7, General Catalyst, Nvidia, Lux Capital, Salesforce Ventures
Why It Matters: By democratizing AI development, Together AI focuses on making open-source generative AI accessible to businesses worldwide, reducing dependence on proprietary AI models.

3. Lambda ($480 Million Series D)

Valuation: $2.5 billion
Specialization: AI infrastructure solutions
Key Investors: SGW, Andra Capital, Nvidia, G Squared, ARK Invest
Why It Matters: Lambda provides the hardware and software backbone needed for large-scale AI computations, positioning itself as a key enabler of AI advancements.

4. Abridge ($250 Million Series D)

Valuation: $2.75 billion
Specialization: AI-powered medical transcription
Key Investors: IVP, Elad Gil, Lightspeed, Redpoint, Spark Capital
Why It Matters: Abridge is revolutionizing healthcare with AI-driven medical transcriptions, improving documentation efficiency and patient care.

5. Eudia ($105 Million Series A)

Specialization: AI-powered legal technology
Key Investors: General Catalyst, Floodgate, Defy Ventures, Everywhere Ventures
Why It Matters: Eudia is streamlining legal workflows with AI, enabling lawyers to automate research, case analysis, and documentation.

6. EnCharge AI ($100 Million Series B)

Specialization: AI hardware solutions
Key Investors: Tiger Global, Scout Ventures, Samsung Ventures, RTX Ventures
Why It Matters: EnCharge AI focuses on improving AI hardware efficiency, ensuring that AI models can run faster with lower energy consumption.

7. Harvey ($300 Million Series D)

Valuation: $3 billion
Specialization: AI for legal tech
Key Investors: Sequoia, OpenAI Startup Fund, Kleiner Perkins, Elad Gil
Why It Matters: Harvey is bringing AI-powered automation to law firms, streamlining legal research and document processing.

8. ElevenLabs ($180 Million Series C)

Valuation: $3 billion+
Specialization: Synthetic voice technology
Key Investors: ICONIQ Growth, Andreessen Horowitz, Sequoia, NEA, Salesforce Ventures
Why It Matters: ElevenLabs is a leader in AI-generated voice synthesis, pushing the boundaries of text-to-speech technology.

9. Hippocratic AI ($141 Million Series B)

Valuation: $1.6 billion+
Specialization: AI models for healthcare
Key Investors: Kleiner Perkins, Andreessen Horowitz, Nvidia, General Catalyst
Why It Matters: Hippocratic AI is focused on developing AI-driven solutions for the healthcare sector, making patient care more efficient and data-driven.

The Future of AI Startups in 2025 and Beyond

With these massive investments, AI startups are expected to accelerate innovation, expanding their reach across multiple industries. The key trends to watch include:

Expansion of Generative AI Applications: Companies like Anthropic and Together AI will continue refining large language models for businesses and consumers.
Advancements in AI Hardware: AI hardware startups such as EnCharge AI are crucial in making AI systems more efficient.
AI in Healthcare: Startups like Abridge and Hippocratic AI are pushing the boundaries of AI’s role in medicine.
Legal and Enterprise AI Solutions: Companies like Eudia and Harvey are transforming traditional industries through AI-powered automation.

Final Thoughts

The AI startup landscape in 2025 is more vibrant than ever, with companies securing billions to innovate and refine AI-driven solutions. Whether it’s generative AI, AI-powered healthcare, or AI-driven legal solutions, these startups are shaping the future of artificial intelligence.

What’s Next?

As AI continues evolving, expect to see more groundbreaking startups emerge, attracting even greater investments. Keep an eye on these game-changing companies as they redefine the possibilities of artificial intelligence.